CANNABIS, MARIJUANA, POT, DOPE, GRASS, WEED, MARY JANE, BUD, GANJA, HASHISH, DOOBIE, BHANG, CHRONIC...
The chemical compound tetrahydrocannabinol (THC) is the psychoactive substance found in cannabis. As in the case of nicotine
, THC's most likely function in Cannabis is to protect the plant from herbivores or pathogens. Its most likely function in humans is to fucking relax, goddamnit.
Did you know?
THC was isolated by Raphael Mechoulam and Yechiel Gaoni from the Weizmann Institute in Rehovot, Israel in 1964.
THC has analgesic effects that, even at low doses, causes a "high", thus leading to the fact that medical cannabis can be used to treat pain. The mechanism for analgesic effects caused directly by THC or other cannabinoid agonists is not fully elucidated. Other effects include: relaxation; euphoria; altered space-time perception; alteration of visual, auditory, and olfactory senses; disorientation; fatigue; and appetite stimulation related to CB1 receptor activity in the central nervous system. The mechanism for appetite stimulation in subjects is somewhat understood and explained through a gastro-hypothalamic axis. CB1 activity in the hunger centres in the hypothalamus that increase the palatability of food, a hunger hormone--ghrelin increases hunger signals as food enters the stomach. After chyme is passed into the duodenum, signaling hormones such as CCK and leptin are released causing reduction in gastric emptying and satiety signals to the hypothalamus, respectively. Cannabinoid activity is reduced through the satiety signals induced by leptin release. It also has anti-emetic properties, and also may reduce aggression in certain subjects.
Recent research has shown that many adverse side effects, generally known as the "stoner" stereotype, fail to hold up to the scientific method. Recent studies with synthetic cannabinoids show that activation of CB1 receptors can facilitate neurogeneration, as well as neuroprotection, and can even help prevent natural neural degradation from neurodegenerative diseases such as MS, Parkinson's, and Alzheimer's. This, along with research into the CB2 receptor (throughout the immune system), has given the case for medical marijuana more support.